Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5
Détails
ID Serval
serval:BIB_6AEE4FDFCBEB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5
Périodique
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804 (Print)
Statut éditorial
Publié
Date de publication
03/2006
Volume
50
Numéro
3
Pages
1100-3
Notes
Journal Article
Research Support, N.I.H., Extramural --- Old month value: Mar
Research Support, N.I.H., Extramural --- Old month value: Mar
Résumé
Histatin 5, a human salivary protein with broad-spectrum antifungal activity, is remarkably ineffective against Candida glabrata. Fluconazole resistance in this fungus is due in most cases to upregulation of CgCDR efflux pumps. We investigated whether the distinct resistance of C. glabrata to histatin 5 is related to similar mechanisms.
Mots-clé
Antifungal Agents/*pharmacology
Candida glabrata/*drug effects/genetics/growth & development
Culture Media
Drug Resistance, Fungal/drug effects/*genetics
Gene Expression Regulation, Fungal/drug effects
*Genes, Fungal
Humans
Salivary Proteins/*pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 15:40
Dernière modification de la notice
20/08/2019 15:25
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