Active intravenous drug use during chronic hepatitis C therapy does not reduce sustained virological response rates in adherent patients.

Détails

ID Serval
serval:BIB_6AE0D4E47053
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Active intravenous drug use during chronic hepatitis C therapy does not reduce sustained virological response rates in adherent patients.
Périodique
Journal of Viral Hepatitis
Auteur⸱e⸱s
Bruggmann P., Falcato L., Dober S., Helbling B., Keiser O., Negro F., Meili D.
ISSN
1352-0504
Statut éditorial
Publié
Date de publication
2008
Volume
15
Numéro
10
Pages
747-752
Langue
anglais
Résumé
SUMMARY: Reluctance has been expressed about treating chronic hepatitis C in active intravenous (IV) drug users (IDUs), and this is found in both international guidelines and routine clinical practice. However, the medical literature provides no evidence for an unequivocal treatment deferral of this risk group. We retrospectively analyzed the direct effect of IV drug use on treatment outcome in 500 chronic hepatitis C patients enrolled in the Swiss Hepatitis C Cohort Study. Patients were eligible for the study if they had their serum hepatitis C virus (HCV) RNA tested 6 months after the end of treatment and at least one visit during the antiviral therapy, documenting the drug use status. Five hundred patients fulfilled the inclusion criteria (199 were IDU and 301 controls). A minimum exposure to 80% of the scheduled cumulative dose of antivirals was reached in 66.0% of IDU and 60.5% of controls (P = NS). The overall sustained virological response (SVR) rate was 63.6%. Active IDU reached a SVR of 69.3%, statistically not significantly different from controls (59.8%). A multivariate analysis for treatment success showed no significant negative influence of active IV drug use. In conclusion, our study shows no relevant direct influence of IV drugs on the efficacy of anti-HCV therapy among adherent patients.
Mots-clé
Adult, Antiviral Agents/therapeutic use, Cohort Studies, Drug Therapy, Combination, Female, Hepacivirus/drug effects, Hepatitis C, Chronic/drug therapy, Hepatitis C, Chronic/virology, Humans, Interferons/classification, Interferons/genetics, Male, Middle Aged, Patient Compliance, Ribavirin/therapeutic use, Substance Abuse, Intravenous/complications, Switzerland, Treatment Outcome
Pubmed
Web of science
Création de la notice
30/09/2009 14:05
Dernière modification de la notice
20/08/2019 14:25
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