Lymphatic vascular morphogenesis in development, physiology, and disease.

Détails

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Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_6AB05975BB07
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Lymphatic vascular morphogenesis in development, physiology, and disease.
Périodique
Journal of Cell Biology
Auteur⸱e⸱s
Schulte-Merker S., Sabine A., Petrova T.V.
ISSN
1540-8140 (Electronic)
ISSN-L
0021-9525
Statut éditorial
Publié
Date de publication
2011
Volume
193
Numéro
4
Pages
607-618
Langue
anglais
Résumé
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases.
Mots-clé
Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells/metabolism, Homeostasis, Humans, Lymph/metabolism, Lymphangiogenesis/genetics, Lymphatic Vessels/embryology, Lymphatic Vessels/metabolism, Lymphedema/genetics, Lymphedema/metabolism, Morphogenesis
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/10/2011 10:35
Dernière modification de la notice
20/08/2019 14:25
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