A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas.

Détails

ID Serval
serval:BIB_6A9A91CF89CE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas.
Périodique
Virchows Archiv
Auteur(s)
Burghaus S., Hölsken A., Buchfelder M., Fahlbusch R., Riederer B.M., Hans V., Blümcke I., Buslei R.
ISSN
1432-2307[electronic], 0945-6317[linking]
Statut éditorial
Publié
Date de publication
03/2010
Peer-reviewed
Oui
Volume
456
Numéro
3
Pages
287-300
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Craniopharyngiomas (CP) are benign epithelial tumors of the sellar region and can be clinicopathologically distinguished into adamantinomatous (adaCP) and papillary (papCP) variants. Both subtypes are classified according to the World Health Organization grade I, but their irregular digitate brain infiltration makes any complete surgical resection difficult to obtain. Herein, we characterized the cellular interface between the tumor and the surrounding brain tissue in 48 CP (41 adaCP and seven papCP) compared to non-neuroepithelial tumors, i.e., 12 cavernous hemangiomas, 10 meningiomas, and 14 metastases using antibodies directed against glial fibrillary acid protein (GFAP), vimentin, nestin, microtubule-associated protein 2 (MAP2) splice variants, and tenascin-C. We identified a specific cell population characterized by the coexpression of nestin, MAP2, and GFAP within the invasion niche of the adamantinomatous subtype. This was especially prominent along the finger-like protrusions. A similar population of presumably astroglial precursors was not visible in other lesions under study, which characterize them as distinct histopathological feature of adaCP. Furthermore, the outer tumor cell layer of adaCP showed a distinct expression of MAP2, a novel finding helpful in the differential diagnosis of epithelial tumors in the sellar region. Our data support the hypothesis that adaCP, unlike other non-neuroepithelial tumors of the central nervous system, create a tumor-specific cellular environment at the tumor-brain junction. Whether this facilitates the characteristic infiltrative growth pattern or is the consequence of an activated Wnt signaling pathway, detectable in 90% of these tumors, will need further consideration.
Mots-clé
Adolescent, Adult, Aged, Brain/metabolism, Child, Child, Preschool, Craniopharyngioma/pathology, Craniopharyngioma/physiopathology, Female, Gene Expression Regulation, Neoplastic, Glial Fibrillary Acidic Protein/metabolism, Humans, Intermediate Filament Proteins/metabolism, Male, Microtubule-Associated Proteins/metabolism, Middle Aged, Neoplasm Invasiveness/pathology, Neoplasm Invasiveness/physiopathology, Neoplasm Metastasis/pathology, Neoplasm Metastasis/physiopathology, Nerve Tissue Proteins/metabolism, Pituitary Neoplasms/pathology, Pituitary Neoplasms/physiopathology, Tenascin/metabolism, Tumor Markers, Biological/metabolism, Vimentin/metabolism
Pubmed
Web of science
Création de la notice
12/03/2010 14:58
Dernière modification de la notice
20/08/2019 14:25
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