Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters.

Détails

ID Serval
serval:BIB_6A990EC69242
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters.
Périodique
Nature
Auteur(s)
Charpak S., Gähwiler B.H., Do K.Q., Knöpfel T.
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
1990
Peer-reviewed
Oui
Volume
347
Numéro
6295
Pages
765-767
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Excitatory amino acids mediate fast synaptic transmission in the central nervous system through the activation of at least three distinct ionotropic receptors: N-methyl-D-aspartate (NMDA), the alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/quisqualate (QUIS) and the kainate subtypes (for reviews, see refs 1, 2). They also activate the additional QUIS 'metabotropic' receptor (sensitive to trans-1-amino-cyclopentyl-1,3-dicarboxylate, ACPD) linked to inositol phospholipid metabolism. We have used hippocampal slice cultures to study the electrophysiological consequences of the metabotropic response. We find that activation of an ACPD-sensitive QUIS receptor produces a 'slow' excitation of CA3 pyramidal cells, resulting from depression of a Ca2(+)-dependent K+ current and a voltage-gated K+ current. Combined voltage-clamp and microfluorometric recordings show that, although these receptors can trigger an increase in intracellular Ca2+ concentration, suppression of K+ currents is independent of changes in intracellular Ca2+. These effects closely resemble those induced by activating muscarinic acetylcholine receptors in the same neurons and suggest that excitatory amino acids not only act as fast ionotropic transmitters but also as slow neuromodulatory transmitters.
Mots-clé
Action Potentials, Animals, Calcium/metabolism, Calcium/pharmacology, Cycloleucine/analogs & derivatives, Cycloleucine/pharmacology, Electric Conductivity, Electrophysiology, Hippocampus/cytology, Hippocampus/physiology, Ibotenic Acid/analogs & derivatives, Ibotenic Acid/pharmacology, Kynurenic Acid/pharmacology, Neurons/physiology, Potassium Channels/physiology, Quisqualic Acid/pharmacology, Rats, Rats, Inbred Strains, Receptors, AMPA, Receptors, Muscarinic/physiology, Receptors, Neurotransmitter/physiology, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Pubmed
Web of science
Création de la notice
06/03/2014 16:34
Dernière modification de la notice
20/08/2019 14:25
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