The GraftConnector experience. Long-term patency and histological work up in an animal model.

Détails

ID Serval
serval:BIB_6A8D40271A30
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The GraftConnector experience. Long-term patency and histological work up in an animal model.
Périodique
Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera
Auteur(s)
Tozzi P., Solem J.O., Boumzebra D., Mucciolo A., Mueller X., von Segesser L.K.
ISSN
0007-1323
1023-9332
Statut éditorial
Publié
Date de publication
2001
Volume
7
Numéro
5
Pages
209-12
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
BACKGROUND: A device to perform sutureless end-to-side coronary artery anastomosis has been developed by means of stent technology (GraftConnector). The present study assesses the long-term quality of the GraftConnector anastomosis in a sheep model. METHODS: In 8 adult sheep, 40-55 kg in weight, through left anterior thoracotomy, the right internal mammary artery (RIMA) was prepared and connected to the left anterior descending artery (LAD) by means of GraftConnector, on beating heart, without using any stabilizer. Ticlopidine 250 mg/day for anticoagulation for 4 weeks and Aspirin 100 mg/day for 6 months were given. The animals were sacrificed after 6 months and histological examination of anastomoses was carried out after slicing with the connector in situ for morphological analysis. RESULTS: All animals survived at 6 months. All anastomoses were patent and mean luminal width at histology was 1.8 +/- 0.2 mm; mean myotomia hyperplasia thickness was 0.21 +/- 0.1 mm. CONCLUSIONS: Long-term results demonstrate that OPCABGs performed with GraftConnector had 100% patency rate. The mean anastomotic luminal width corresponds to mean LAD's adult sheep diameter. We may speculate that myotomia hyperplasia occurred as a result of local device oversizing.
Mots-clé
Animals, Coronary Vessels, Fibromuscular Dysplasia, Internal Mammary-Coronary Artery Anastomosis, Sheep, Vascular Patency, Wound Healing
Pubmed
Création de la notice
28/01/2008 9:42
Dernière modification de la notice
20/08/2019 14:25
Données d'usage