Identification of bioactive metabolites using activity metabolomics.

Détails

ID Serval
serval:BIB_6A7D7B7C85F9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Identification of bioactive metabolites using activity metabolomics.
Périodique
Nature reviews. Molecular cell biology
Auteur(s)
Rinschen M.M., Ivanisevic J., Giera M., Siuzdak G.
ISSN
1471-0080 (Electronic)
ISSN-L
1471-0072
Statut éditorial
Publié
Date de publication
06/2019
Peer-reviewed
Oui
Volume
20
Numéro
6
Pages
353-367
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The metabolome, the collection of small-molecule chemical entities involved in metabolism, has traditionally been studied with the aim of identifying biomarkers in the diagnosis and prediction of disease. However, the value of metabolome analysis (metabolomics) has been redefined from a simple biomarker identification tool to a technology for the discovery of active drivers of biological processes. It is now clear that the metabolome affects cellular physiology through modulation of other 'omics' levels, including the genome, epigenome, transcriptome and proteome. In this Review, we focus on recent progress in using metabolomics to understand how the metabolome influences other omics and, by extension, to reveal the active role of metabolites in physiology and disease. This concept of utilizing metabolomics to perform activity screens to identify biologically active metabolites - which we term activity metabolomics - is already having a broad impact on biology.
Mots-clé
Animals, Biomarkers/metabolism, Humans, Metabolome, Metabolomics
Pubmed
Web of science
Création de la notice
12/03/2019 21:34
Dernière modification de la notice
06/03/2020 6:20
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