Whole-body protein turnover and resting energy expenditure in obese, prepubertal children.

Détails

ID Serval
serval:BIB_6A4D4F0A36D7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Whole-body protein turnover and resting energy expenditure in obese, prepubertal children.
Périodique
American Journal of Clinical Nutrition
Auteur(s)
Schutz Y., Rueda-Maza C.M., Zaffanello M., Maffeis C.
ISSN
0002-9165 (Print)
ISSN-L
0002-9165
Statut éditorial
Publié
Date de publication
05/1999
Volume
69
Numéro
5
Pages
857-862
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: Obesity is becoming more frequent in children; understanding the extent to which this condition affects not only carbohydrate and lipid metabolism but also protein metabolism is of paramount importance.
OBJECTIVE: We evaluated the kinetics of protein metabolism in obese, prepubertal children in the static phase of obesity.
DESIGN: In this cross-sectional study, 9 obese children (x +/- SE: 44+/-4 kg, 30.9+/-1.5% body fat) were compared with 8 lean (28+/-2 kg ,16.8+/-1.2% body fat), age-matched (8.5+/-0.2 y) control children. Whole-body nitrogen flux, protein synthesis, and protein breakdown were calculated postprandially over 9 h from 15N abundance in urinary ammonia by using a single oral dose of [15N]glycine; resting energy expenditure (REE) was assessed by indirect calorimetry (canopy) and body composition by multiple skinfold-thickness measurements.
RESULTS: Absolute rates of protein synthesis and breakdown were significantly greater in obese children than in control children (x +/- SE: 208+/-24 compared with 137+/-14 g/d, P < 0.05, and 149+/-20 compared with 89+/-13 g/d, P < 0.05, respectively). When these variables were adjusted for fat-free mass by analysis of covariance, however, the differences between groups disappeared. There was a significant relation between protein synthesis and fat-free mass (r = 0.83, P < 0.001) as well as between protein synthesis and REE (r = 0.79, P < 0.005).
CONCLUSIONS: Obesity in prepubertal children is associated with an absolute increase in whole-body protein turnover that is consistent with an absolute increase in fat-free mass, both of which contribute to explaining the greater absolute REE in obese children than in control children.
Mots-clé
Child, Energy Metabolism, Humans, Nitrogen/metabolism, Obesity/metabolism, Protein Biosynthesis, Proteins/metabolism, Puberty
Pubmed
Web of science
Création de la notice
21/01/2008 13:08
Dernière modification de la notice
20/08/2019 14:25
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