Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals.

Détails

ID Serval
serval:BIB_69DAC24E95CC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals.
Périodique
Cold Spring Harbor Symposia on Quantitative Biology
Auteur⸱e⸱s
Schibler U., Gotic I., Saini C., Gos P., Curie T., Emmenegger Y., Sinturel F., Gosselin P., Gerber A., Fleury-Olela F., Rando G., Demarque M., Franken P.
ISSN
1943-4456 (Electronic)
ISSN-L
0091-7451
Statut éditorial
Publié
Date de publication
2015
Volume
80
Pages
223-232
Langue
anglais
Résumé
In mammals, including humans, nearly all physiological processes are subject to daily oscillations that are governed by a circadian timing system with a complex hierarchical structure. The central pacemaker, residing in the suprachiasmatic nucleus (SCN) of the ventral hypothalamus, is synchronized daily by photic cues transmitted from the retina to SCN neurons via the retinohypothalamic tract. In turn, the SCN must establish phase coherence between self-sustained and cell-autonomous oscillators present in most peripheral cell types. The synchronization signals (Zeitgebers) can be controlled more or less directly by the SCN. In mice and rats, feeding-fasting rhythms, which are driven by the SCN through rest-activity cycles, are the most potent Zeitgebers for the circadian oscillators of peripheral organs. Signaling through the glucocorticoid receptor and the serum response factor also participate in the phase entrainment of peripheral clocks, and these two pathways are controlled by the SCN independently of feeding-fasting rhythms. Body temperature rhythms, governed by the SCN directly and indirectly through rest-activity cycles, are perhaps the most surprising cues for peripheral oscillators. Although the molecular makeup of circadian oscillators is nearly identical in all cells, these oscillators are used for different purposes in the SCN and in peripheral organs.
Pubmed
Open Access
Oui
Création de la notice
07/01/2016 18:32
Dernière modification de la notice
20/08/2019 15:24
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