Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life.

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Version: Final published version
ID Serval
serval:BIB_6990F70049C3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life.
Périodique
Molecular Biology and Evolution
Auteur(s)
Sojo V., Dessimoz C., Pomiankowski A., Lane N.
ISSN
1537-1719 (Electronic)
ISSN-L
0737-4038
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
33
Numéro
11
Pages
2874-2884
Langue
anglais
Résumé
Membrane proteins are crucial in transport, signaling, bioenergetics, catalysis, and as drug targets. Here, we show that membrane proteins have dramatically fewer detectable orthologs than water-soluble proteins, less than half in most species analyzed. This sparse distribution could reflect rapid divergence or gene loss. We find that both mechanisms operate. First, membrane proteins evolve faster than water-soluble proteins, particularly in their exterior-facing portions. Second, we demonstrate that predicted ancestral membrane proteins are preferentially lost compared with water-soluble proteins in closely related species of archaea and bacteria. These patterns are consistent across the whole tree of life, and in each of the three domains of archaea, bacteria, and eukaryotes. Our findings point to a fundamental evolutionary principle: membrane proteins evolve faster due to stronger adaptive selection in changing environments, whereas cytosolic proteins are under more stringent purifying selection in the homeostatic interior of the cell. This effect should be strongest in prokaryotes, weaker in unicellular eukaryotes (with intracellular membranes), and weakest in multicellular eukaryotes (with extracellular homeostasis). We demonstrate that this is indeed the case. Similarly, we show that extracellular water-soluble proteins exhibit an even stronger pattern of low homology than membrane proteins. These striking differences in conservation of membrane proteins versus water-soluble proteins have important implications for evolution and medicine.

Mots-clé
membrane proteins, orthologs, homeostasis, evolution, adaptation
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/08/2016 16:19
Dernière modification de la notice
20/08/2019 15:24
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