Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals

Détails

ID Serval
serval:BIB_695918510668
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Pestov  N. B., Ahmad  N., Korneenko  T. V., Zhao  H., Radkov  R., Schaer  D., Roy  S., Bibert  S., Geering  K., Modyanov  N. N.
ISSN
0027-8424 (Print)
Statut éditorial
Publié
Date de publication
07/2007
Volume
104
Numéro
27
Pages
11215-20
Notes
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Jul 3
Résumé
Change in gene functions (gene cooption) is one of the key mechanisms of molecular evolution. Genes can acquire new functions via alteration in properties of encoded proteins and/or via changes in temporal or spatial regulation of expression. Here we demonstrate radical changes in the functions of orthologous ATP1B4 genes during evolution of vertebrates. Expression of ATP1B4 genes is brain-specific in teleost fishes, whereas it is predominantly muscle-specific in tetrapods. The encoded beta m-proteins in fish, amphibian, and avian species are beta-subunits of Na,K-ATPase located in the plasma membrane. In placental mammals beta m-proteins lost their ancestral functions, accumulate in nuclear membrane of perinatal myocytes, and associate with transcriptional coregulator Ski-interacting protein (SKIP). Through interaction with SKIP, eutherian beta m acquired new functions as exemplified by regulation of TGF-beta-responsive reporters and by augmentation of mRNA levels of Smad7, an inhibitor of TGF-beta signaling. Thus, orthologous vertebrate ATP1B4 genes represent an instance of gene cooption that created fundamental changes in the functional properties of the encoded proteins.
Mots-clé
Amino Acid Sequence Animals Chick Embryo Chickens *Evolution, Molecular Humans Mice Molecular Sequence Data Muscle, Skeletal/cytology/metabolism/physiology Na(+)-K(+)-Exchanging ATPase/biosynthesis/*chemistry/genetics/*physiology Nuclear Proteins/physiology Protein Subunits/biosynthesis/*chemistry/genetics/*physiology Rats Tetraodontiformes Transcription Factors/*chemistry/genetics/*physiology Xenopus laevis
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:28
Dernière modification de la notice
20/08/2019 15:24
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