Implication of dipeptidylpeptidase IV activity in human bronchial inflammation and in bronchoconstriction evaluated in anesthetized rabbits.

Détails

ID Serval
serval:BIB_690ADDBD86AB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Implication of dipeptidylpeptidase IV activity in human bronchial inflammation and in bronchoconstriction evaluated in anesthetized rabbits.
Périodique
Respiration
Auteur(s)
Landis B.N., Grouzmann E., Monod M., Busso N., Petak F., Spiliopoulos A., Robert J.H., Szalay-Quinodoz I., Morel D.R., Lacroix J.S.
ISSN
1423-0356
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
75
Numéro
1
Pages
89-97
Langue
anglais
Notes
Journal article --- Old month value: Jul 18
Résumé
BACKGROUND: Decreased dipeptidylpeptidase IV (DPPIV) activity within the human nasal mucosa has previously been shown to contribute to the severity of chronic inflammatory rhinosinusitis. OBJECTIVE: To investigate and correlate the role of DPPIV activity with regard to bronchial inflammation. METHODS: DPPIV/CD26 activity/concentration was investigated in the bronchial tissue of human subjects suffering from chronic bronchial inflammation. In addition, the effect of a recombinant Aspergillus fumigatus DPPIV (fuDPPIV) was investigated on histamine-induced bronchoconstriction in anesthetized rabbits. RESULTS AND CONCLUSIONS: DPPIV/CD26 was present in submucosal seromucous glands, in leukocytes and to a very low degree in endothelial cells of human bronchi. DPPIV activity was correlated with tissue CD26 content measured by immunoassay. As previously reported for the nasal mucosa, DPPIV/CD26 activity was inversely correlated with the degree of airway inflammation. Systemic pretreatment with recombinant fuDPPIV markedly reduced the increase in histamine-induced airway resistance in rabbits. In conclusion, DPPIV activity modulates lower airway tone by degrading unknown peptidic substrates released by histamine in response to an allergen. Contrasting with our observations in the nose, this modulation is apparently not mediated via a neurokinin (NK1) receptor.
Mots-clé
Adult, Aged, Aged, 80 and over, Analysis of Variance, Animals, Antigens, CD26, Biological Markers, Bronchial Hyperreactivity, Bronchitis, Chronic, Bronchoconstriction, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Female, Histamine, Humans, Immunohistochemistry, Male, Middle Aged, Nasal Mucosa, Probability, Rabbits, Reference Values, Sampling Studies, Sensitivity and Specificity, Severity of Illness Index, Substance P
Pubmed
Web of science
Création de la notice
25/01/2008 11:55
Dernière modification de la notice
20/08/2019 15:24
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