UV radiation-induced skin tumors in Monodelphis domestica

Détails

ID Serval
serval:BIB_68F72AD31C8B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
UV radiation-induced skin tumors in Monodelphis domestica
Périodique
Photo-Dermatology
Auteur⸱e⸱s
Ley  R. D., Applegate  L. A., Stuart  T. D., Fry  R. J.
ISSN
0108-9684 (Print)
Statut éditorial
Publié
Date de publication
1987
Volume
4
Numéro
3
Pages
144-147
Notes
DA - 19880105
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
SB - IM
Résumé
Chronic exposure of the skin of the South American opossum (Monodelphis domestica) to ultraviolet radiation (UVR) from an FS-40 sunlamp (280-400 nm) 3 times per week for a total of 200 exposures resulted in the appearance of actinic keratoses, fibrosarcomas, squamous cell carcinomas and keratoacanthomas. At the higher doses of UVR used in this study, moderate to severe hyperplasia was also observed. The susceptibility of this animal to the induction of skin tumors by UVR in conjunction with the capacity to enzymatically photoreactive pyrimidine dimers in cutaneous DNA identifies this animal as a useful model in determining the role of pyrimidine dimers in skin tumor induction by UVR
Mots-clé
adverse effects/Animals/Carcinoma,Squamous Cell/Disease Models,Animal/etiology/Fibrosarcoma/Humans/Hyperplasia/Neoplasms,Radiation-Induced/Opossums/pathology/Radiation Dosage/Skin/Skin Neoplasms/Ultraviolet Rays
Pubmed
Web of science
Création de la notice
18/02/2008 17:33
Dernière modification de la notice
20/08/2019 14:24
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