Adiponectin and C-reactive protein are positively associated with microalbuminuria in an adult Caucasian population

Détails

ID Serval
serval:BIB_68A7CE845E5F
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Adiponectin and C-reactive protein are positively associated with microalbuminuria in an adult Caucasian population
Titre de la conférence
20th Annual Meeting of the European Society of Hypertension
Auteur(s)
Pruijm Menno, Vollenweider Peter, Mooser Vincent, Marques-Vidal Pedro Manuel, Teta Daniel, Paccaud Fred, Waeber Gérard, Burnier Michel, Bochud Murielle
Adresse
Oslo, NORWAY, Jun 18-21, 2010
ISBN
0263-6352
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
28
Série
Journal of Hypertension
Pages
E558-E558
Langue
anglais
Notes
Meeting Abstract
http://journals.lww.com/jhypertension/Fulltext/2010/06001/Adiponectin_and_C_Reactive_Protein_Are_Positively.1639.aspx
Résumé
Objective: Microalbuminuria (MAU) is a marker of early kidney injury and
cardiovascular risk. We assessed the association of MAU with plasma adiponectin, leptin, and hsCRP as inflammatory marker, accounting for hypertension, diabetes and obesity. Design and Methods: Population based, cross-sectional study in Caucasian subjects aged 35 to 75 years in Lausanne, Switzerland. MAU, measured by quantitative immunonephelometry on spot morning urine, was used either as a continuous (MAU) or dichotomized variable (MA defined as MAU > 2.5 and >3.5 mg/mmol creatinine in men and women, respectively).
Results: The 2955 women (age 53.3_10.7, mean_SD years) had mean body mass index (BMI) 24.9_4.5 kg/m. The 2479 men (age 53.1_10.8 years) hadmean BMI 27.0_3.9 kg/m2.Median hsCRP was 1.3 and 1.3 mg/L, median adiponectin 6.2 and 10.6mg/mL in men and women, respectively. MA prevalence was 4.9% in women and 9.8% in men. In multivariate regression analysis adjusting for potential confounders (age, sex, hypertension, diabetes, eGFR, BMI, percent fat mass, insulin and smoking), logtransformed MAU was positively associated with hsCRP (P<0.001) and adiponectin (P¼0.002), but not with leptin. The association of adiponectin with MAU was stronger in subjects with low hsCRP, and vice versa (P interaction<0.001).
Conclusion: Adiponectin and hsCRP are significant positive determinants of MAU, independently of diabetes, hypertension and fat mass. A negative interaction between hsCRP and adiponectin was found for their effect on MAU. Whether hyperadiponectinemia represents an adequate protective response to vascular stress or has negative causal impact on the development of MAU should be assessed in further studies.
Web of science
Création de la notice
20/01/2011 11:51
Dernière modification de la notice
20/08/2019 15:23
Données d'usage