Pneumocystis jirovecii pneumonia: still a concern in patients with haematological malignancies and stem cell transplant recipients.

Détails

ID Serval
serval:BIB_687A58D266A8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Pneumocystis jirovecii pneumonia: still a concern in patients with haematological malignancies and stem cell transplant recipients.
Périodique
Journal of Antimicrobial Chemotherapy
Auteur(s)
Cordonnier C., Cesaro S., Maschmeyer G., Einsele H., Donnelly J.P., Alanio A., Hauser P.M., Lagrou K., Melchers W.J., Helweg-Larsen J., Matos O., Bretagne S., Maertens J., Fifth European Conference on Infections in Leukemia (ECIL-5)  a joint venture of The European Group for Blood, Marrow Transplantation (EBMT)  The European Organization for Research, Treatment of Cancer (EORTC)  the Immunocompromised Host Society (ICHS)
Collaborateur(s)
The European LeukemiaNet (ELN)
Contributeur(s)
Agrawal S., Akova M., Alanio A., Aljurf M., Averbuch D., Berg T., Blennow O., Bretagne S., Brüggemann R., Calandra T., Castagnola E., Cesaro S., Cordonnier C., Cornely O., De La Camara R., Donnelly P., Drgona L., Duarte R., Einsele H., Engelhard D., Girmenia C., Hargreaves R., Hauser P., Helweg-Larsen J., Herbrecht R., Hirsch H., Hubacek P., Kibbler C., Klyasova G., Kouba M., Kullberg BJ., Lagrou K., Ljungman P., Maertens J., Mallet V., Marchetti O., Maschmeyer G., Matos O., Melchers W., Mikulska M., Munoz P., Orasch C., Pagano L., Pagliuca A., Penack O., Pettrikos G., Racil Z., Ribaud P., Rizzi-Puechal V., Roilides E., Sinko J., Skiada A., Slavin M., Styczynski J., Tissot F., Tweddle L., van Boemmel F., von Lilienfeld-Toal M., Viscoli C., Ward K., Wood C.
ISSN
1460-2091 (Electronic)
ISSN-L
0305-7453
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
71
Numéro
9
Pages
2379-2385
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Pneumocystis jirovecii can cause life-threatening pneumonia following treatment for haematological malignancies or after HSCT. The mortality rate of P. jirovecii pneumonia (PCP) in these patients is 30%-60%, especially after HSCT. The clinical presentation of PCP in haematology differs from that associated with HIV infection, with the disease being acute and more often severe, having a lower fungal burden and being more frequently linked to treatment with corticosteroids. Most cases occur in patients not receiving adequate prophylaxis. The development of new therapies, including targeted treatments and monoclonal antibodies in various haematological diseases, justifies constant vigilance in order to identify new at-risk populations and give prophylaxis accordingly. The fifth and sixth European Conferences on Infections in Leukaemia (ECIL-5 and ECIL-6) aimed to review risk factors for PCP in haematology patients and to establish evidence-based recommendations for PCP diagnosis, prophylaxis and treatment. This article focuses on the magnitude of the problem, the main differences in clinical presentation between haematology patients and other immunocompromised populations, especially HIV-infected patients, and the main risk factors.
Pubmed
Open Access
Oui
Création de la notice
16/09/2016 17:23
Dernière modification de la notice
25/02/2021 15:44
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