Current and future developments in the use of temozolomide for the treatment of brain tumours

Détails

ID Serval
serval:BIB_674DBF293AF4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Current and future developments in the use of temozolomide for the treatment of brain tumours
Périodique
Lancet Oncology
Auteur⸱e⸱s
Stupp  R., Gander  M., Leyvraz  S., Newlands  E.
ISSN
1470-2045 (Print)
Statut éditorial
Publié
Date de publication
09/2001
Volume
2
Numéro
9
Pages
552-60
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep
Résumé
Brain tumours comprise only 2% of all adult cancers, but they are among the most debilitating malignant diseases. Temozolomide, an alkylating agent that can be administered orally, has been approved for the treatment of recurrent malignant glioma on a daily schedule for 5-day cycles. Continuous administration schedules with a higher dose intensity are being explored, but an improvement in efficiency remains to be shown. The benefit from temozolomide given as a single agent in recurrent disease will be several weeks at best. This drug is therefore now undergoing clinical testing as neoadjuvant chemotherapy or with concomitant radiotherapy in patients with newly diagnosed glioma. Several phase I trials are investigating the combination of temozolomide with other agents active against brain tumours. This review briefly summarises the pharmacological background and clinical development of temozolomide and focuses on current and future clinical exploration of this drug for the treatment of brain tumours.
Mots-clé
Antineoplastic Agents, Alkylating/*therapeutic use Brain Neoplasms/*drug therapy/radiotherapy Combined Modality Therapy Dacarbazine/analogs & derivatives/*therapeutic use Drug Resistance, Neoplasm Glioma/drug therapy Humans Neoplasm Recurrence, Local/drug therapy
Pubmed
Web of science
Création de la notice
28/01/2008 9:39
Dernière modification de la notice
20/08/2019 15:22
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