T-cell-independent antiviral B cell responses in CD45-deficient mice

Détails

ID Serval
serval:BIB_674B825DE490
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
T-cell-independent antiviral B cell responses in CD45-deficient mice
Périodique
Cellular Immunology
Auteur(s)
Bachmann  M. F., Kundig  T. M., Speiser  D. E., McKall-Faienza  K., Kishara  K., Mak  T. W., Ohashi  P. S.
ISSN
0008-8749 (Print)
Statut éditorial
Publié
Date de publication
01/1997
Volume
175
Numéro
1
Pages
12-5
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 10
Résumé
CD45 is expressed on all B cells and has been reported to be essential for their B cell receptor mediated stimulation. The present study addressed T-cell-independent B cell responses in CD45-deficient mice using the glycoprotein (G) of vesicular stomatitis virus (VSV) as a model antigen. VSV-G exists in two forms exhibiting different degrees of repetitiveness. In mice, the two forms of VSV-G induce either a type 1 or a type 2 T-cell-independent B cell response. We found that CD45-deficient mice mounted T-cell-independent B cell responses to both forms of VSV-G. This demonstrates that the B cell receptor complex is able to generate a functional signal in the absence of CD45, provided the cross-linking stimulus is sufficiently strong.
Mots-clé
Animals Antibodies, Viral/biosynthesis Antigens, CD45/genetics/*metabolism Antigens, Viral B-Lymphocytes/enzymology/*immunology Cross-Linking Reagents Gene Targeting Glycoproteins/immunology Immunoglobulin M/biosynthesis Lymphocyte Activation *Membrane Glycoproteins Mice Mice, Mutant Strains Neutralization Tests Receptors, Antigen, B-Cell/metabolism T-Lymphocytes, Helper-Inducer/immunology Vesicular stomatitis-Indiana virus/*immunology Viral Envelope Proteins/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:32
Dernière modification de la notice
20/08/2019 15:22
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