The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy.

Détails

Ressource 1Télécharger: BIB_673AC528840D.P001.pdf (596.83 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_673AC528840D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy.
Périodique
Current Opinion in Pharmacology
Auteur⸱e⸱s
Pasero C., Speiser D.E., Derré L., Olive D.
ISSN
1471-4973 (Electronic)
ISSN-L
1471-4892
Statut éditorial
Publié
Date de publication
2012
Volume
12
Numéro
4
Pages
478-485
Langue
anglais
Résumé
The regulation of the immune system is controlled by many cell surface receptors. A prominent representative is the 'molecular switch' HVEM (herpes virus entry mediator) that can activate either proinflammatory or inhibitory signaling pathways. HVEM ligands belong to two distinct families: the TNF-related cytokines LIGHT and lymphotoxin-α, and the Ig-related membrane proteins BTLA and CD160. HVEM and its ligands have been involved in the pathogenesis of various autoimmune and inflammatory diseases, but recent reports indicate that this network may also be involved in tumor progression and resistance to immune response. Here we summarize the recent advances made regarding the knowledge on HVEM and its ligands in cancer cells, and their potential roles in tumor progression and escape to immune responses. Blockade or enhancement of these pathways may help improving cancer therapy.
Mots-clé
Animals, Antigens, CD/immunology, GPI-Linked Proteins/immunology, Humans, Neoplasms/drug therapy, Neoplasms/immunology, Receptors, Immunologic/immunology, Receptors, Tumor Necrosis Factor, Member 14/immunology, Tumor Necrosis Factor Ligand Superfamily Member 14/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/11/2012 14:26
Dernière modification de la notice
20/08/2019 14:22
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