Evidence for pancreas injury in adult respiratory distress syndrome

Détails

ID Serval
serval:BIB_6729992E392C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evidence for pancreas injury in adult respiratory distress syndrome
Périodique
American Review of Respiratory Disease
Auteur⸱e⸱s
Nicod  L., Leuenberger  P., Seydoux  C., Rey  F., Van Melle  G., Perret  C.
ISSN
0003-0805 (Print)
Statut éditorial
Publié
Date de publication
05/1985
Volume
131
Numéro
5
Pages
696-9
Notes
Comparative Study
Journal Article --- Old month value: May
Résumé
The purpose of this study was to investigate the relation between serum lipase (LP), serum immunoreactive trypsin (IRT), and its inhibitors in patients with adult respiratory distress syndrome (ARDS) of diverse origin and to compare their time course with other acute conditions. The IRT and LP levels were determined at regular intervals in 41 patients hospitalized in the intensive respiratory unit with ARDS (n = 9), acute pancreatitis (n = 5), shock (n = 9), bronchopneumonia (n = 10), or acute cardiogenic pulmonary edema (n = 8). Several trypsin inhibitors were measured simultaneously: serum trypsin inhibitory capacity (TIC), alpha 1-antitrypsin, alpha 2-macroglobulin, and antithrombin III. Concomitantly, angiotensin-converting enzyme (ACE) activity was determined as a potential marker of the endothelial injury. A respective 19- and 13-fold increase in IRT and LP values were observed in patients with ARDS after a mean evolution of 6 days; similar increases were seen in patients with pancreatitis. These values were significantly higher than those observed in the other conditions studied. In patients with ARDS and acute pancreatitis, the evolution of IRT and LP values were associated with a sixfold rise in TIC. A low TIC/IRT ratio in patients with ARDS appeared to be an index of poor prognosis. Conversely, ACE activity evolution was characterized by an early decrease in all the conditions studied. These observations indicate that there is an acute delayed pancreas injury in ARDS. Thus, the release of pancreatic enzymes are not reliable markers of the early evolution of the disease but they may represent secondary mediators for enhancement of the increased endothelial permeability.
Mots-clé
Adult Female Humans Lipase/blood Male Middle Aged Pancreatitis/*complications Peptidyl-Dipeptidase A/blood Respiratory Distress Syndrome, Adult/*complications Time Factors Trypsin/blood/immunology Trypsin Inhibitors/blood
Pubmed
Web of science
Création de la notice
28/01/2008 10:11
Dernière modification de la notice
20/08/2019 14:22
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