High incidence of childhood hemolytic uremic syndrome in Switzerland is associated with indicators of livestock farming intensity
Détails
ID Serval
serval:BIB_66B848E058FD
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
High incidence of childhood hemolytic uremic syndrome in Switzerland is associated with indicators of livestock farming intensity
Titre de la conférence
Joint annual meeting of the Swiss Society for Pediatrics, Swiss Society of Pediatric Pneumology
Adresse
Crans Montana, Switzerland, June 17-18, 2010
ISBN
1424-7860
Statut éditorial
Publié
Date de publication
2010
Volume
140
Série
Swiss Medical Weekly
Pages
37S
Langue
anglais
Notes
Meeting Abstract
Résumé
Background: Hemolytic-uremic syndrome (HUS) is a multisystem
disorder associated with significant morbidity and mortality. Typically,
HUS is preceded by an episode of (bloody) diarrhea mostly due to
Shiga-toxin (Stx) producing Escherichia coli (STEC). The main
reservoir for STEC is the intestine of healthy ruminants, mostly cattle,
and recent studies have revealed an association between indicators
of livestock density and human STEC infection or HUS, respectively.
Nationwide data on HUS in Switzerland have been established
through the Swiss Pediatric Surveillance Unit (SPSU) [Schifferli et al.
Eur J Pediatr. 2010; 169:591-8].
Aims: Analysis of age-specific incidence rate of childhood HUS and
possible association of Shiga-toxin associated HUS (Stx-HUS) with
indicators of livestock farming intensity.
Methods: Epidemiological and ecological analysis based on the
SPSU data (1997-2003) and the database of the Swiss Federal
Statistical Office (data on population and agriculture).
Results: One hundred-fourteen cases were registered, 88% were
≤5 years old. The overall annual incidence rate was 1.42 (0.60-1.91)
and 4.23 (1.76-6.19) per 100000 children ≤5 and ≤16 years,
respectively (P = 0.005). Stx-HUS was more frequent compared to
cases not associated with STEC (P = 0.002). The incidence rate for
Stx-HUS was 3.85 (1.76-5.65) in children ≤5, compared to 0.27
(0.00-0.54) per 100'000 children 5-16 years (P = 0.002), respectively.
The incidence rate of cases not associated with STEC infection did not
significantly vary with age (P = 0.107). Compared to data from
Scotland, Canada, Ireland, Germany, England, Australia, Italy, and
Austria the annual incidence rate of HUS in young children is highest
in Switzerland. Ecological analysis revealed strong association
between the incidence rate of Stx-HUS and indicators of rural
occupation (agricultural labourer / population, P = 0.030), farming
intensity (livestock breeding farms / population, P = 0.027) and cattle
density (cattle / cultivated area, P = 0.013).
Conclusions: Alike in other countries, HUS in Switzerland is mostly
associated with STEC infection and affects predominantly young
children. However, the incidence rate is higher compared to countries
abroad and is significantly correlated with indicators of livestock
farming intensity. The present data support the impact of direct and
indirect contact with animals or fecal contaminants in transmission of
STEC to humans.
disorder associated with significant morbidity and mortality. Typically,
HUS is preceded by an episode of (bloody) diarrhea mostly due to
Shiga-toxin (Stx) producing Escherichia coli (STEC). The main
reservoir for STEC is the intestine of healthy ruminants, mostly cattle,
and recent studies have revealed an association between indicators
of livestock density and human STEC infection or HUS, respectively.
Nationwide data on HUS in Switzerland have been established
through the Swiss Pediatric Surveillance Unit (SPSU) [Schifferli et al.
Eur J Pediatr. 2010; 169:591-8].
Aims: Analysis of age-specific incidence rate of childhood HUS and
possible association of Shiga-toxin associated HUS (Stx-HUS) with
indicators of livestock farming intensity.
Methods: Epidemiological and ecological analysis based on the
SPSU data (1997-2003) and the database of the Swiss Federal
Statistical Office (data on population and agriculture).
Results: One hundred-fourteen cases were registered, 88% were
≤5 years old. The overall annual incidence rate was 1.42 (0.60-1.91)
and 4.23 (1.76-6.19) per 100000 children ≤5 and ≤16 years,
respectively (P = 0.005). Stx-HUS was more frequent compared to
cases not associated with STEC (P = 0.002). The incidence rate for
Stx-HUS was 3.85 (1.76-5.65) in children ≤5, compared to 0.27
(0.00-0.54) per 100'000 children 5-16 years (P = 0.002), respectively.
The incidence rate of cases not associated with STEC infection did not
significantly vary with age (P = 0.107). Compared to data from
Scotland, Canada, Ireland, Germany, England, Australia, Italy, and
Austria the annual incidence rate of HUS in young children is highest
in Switzerland. Ecological analysis revealed strong association
between the incidence rate of Stx-HUS and indicators of rural
occupation (agricultural labourer / population, P = 0.030), farming
intensity (livestock breeding farms / population, P = 0.027) and cattle
density (cattle / cultivated area, P = 0.013).
Conclusions: Alike in other countries, HUS in Switzerland is mostly
associated with STEC infection and affects predominantly young
children. However, the incidence rate is higher compared to countries
abroad and is significantly correlated with indicators of livestock
farming intensity. The present data support the impact of direct and
indirect contact with animals or fecal contaminants in transmission of
STEC to humans.
Web of science
Création de la notice
08/09/2010 14:40
Dernière modification de la notice
20/08/2019 14:22
Données d'usage
