The study of physiological disruptions induced upon exposure to a given
chemical substance has emerged as a research field. The assessment of
the effects of chemical substances at low concentration levels is not
always doable using classical toxicological studies. The use of
metabolomics approaches integrated with conventional toxicological
studies is expected to provide valuable information for risk assessment.
This review recapitulates some of the recent publications related to the
use of metabolomics to study the effect of bisphenol A (BPA) and
phthalates exposure. Mass spectrometry and nuclear magnetic resonance
metabolomics approaches revealed the principal metabolic pathways such
as amino acids, energy storage compounds, or organic osmolytes were
altered. To investigate phthalates and BPA effects is relevant to assist
in potential correlations between exposure and adverse human effects and
to provide data and evidence for effective regulatory policies and risk
exposure assessment.