Asymmetric distribution of phosphatidylethanolamine in C. albicans: possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily

Détails

ID Serval
serval:BIB_6694C88B8B42
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Asymmetric distribution of phosphatidylethanolamine in C. albicans: possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily
Périodique
Yeast
Auteur⸱e⸱s
Dogra  S., Krishnamurthy  S., Gupta  V., Dixit  B. L., Gupta  C. M., Sanglard  D., Prasad  R.
ISSN
0749-503X (Print)
Statut éditorial
Publié
Date de publication
01/1999
Volume
15
Numéro
2
Pages
111-21
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 30
Résumé
By using two molecular probes, we demonstrate that only 4% of total phosphatidylethanolamine (PtdEtn) in the plasma membrane (PM) of a human pathogenic yeast, Candida albicans, is present in its external half. Evidence is presented to show that the availability of PtdEtn could be related to the expression of a multidrug transporter CDR1 of C. albicans, and the process is energy-dependent. A homozygous CDR1 disruptant strain of C. albicans shows almost 23% reduction in the external labelling of PtdEtn. This report shows that, similar to human MDRs, yeast multidrug transporter could also be involved in aminophospholipid translocation.
Mots-clé
ATP-Binding Cassette Transporters/*metabolism Adenosine Triphosphate/metabolism Candida albicans/chemistry/drug effects/genetics/*metabolism Drug Resistance, Microbial Drug Resistance, Multiple Fluorescamine/metabolism Fungal Proteins/*metabolism Membrane Lipids/analysis/metabolism Membrane Proteins/metabolism *Membrane Transport Proteins Phosphatidylethanolamines/*analysis/metabolism Trinitrobenzenesulfonic Acid/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 14:40
Dernière modification de la notice
20/08/2019 14:22
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