A five-year study of severe community-acquired pneumonia with emphasis on prognosis in patients admitted to an intensive care unit

Détails

ID Serval
serval:BIB_666059693E88
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A five-year study of severe community-acquired pneumonia with emphasis on prognosis in patients admitted to an intensive care unit
Périodique
Intensive Care Med
Auteur⸱e⸱s
Leroy O., Santre C., Beuscart C., Georges H., Guery B., Jacquier J. M., Beaucaire G.
ISSN
0342-4642 (Print)
ISSN-L
0342-4642
Statut éditorial
Publié
Date de publication
01/1995
Volume
21
Numéro
1
Pages
24-31
Langue
anglais
Notes
Leroy, O
Santre, C
Beuscart, C
Georges, H
Guery, B
Jacquier, J M
Beaucaire, G
eng
Intensive Care Med. 1995 Jan;21(1):24-31. doi: 10.1007/BF02425150.
Résumé
OBJECTIVES: To characterize the epidemiology and to determine the prognosis factors in severe community-acquired pneumonia among patients admitted to an intensive care unit. DESIGN: Retrospective clinical study. SETTING: Intensive Care and Infectious Diseases Unit of a municipal general hospital of Lille University Medical School. PATIENTS: 299 consecutive patients exhibiting severe community-acquired pneumonia. MEASUREMENTS AND RESULTS: On admission to ICU, 149 patients required mechanical ventilation for acute respiratory failure and 44 exhibited septic shock. Pulmonary involvement was bilateral in 71 patients. There were 260 organisms isolated from 197 patients (65.9%), the most frequent being Streptococcus pneumoniae (n = 80), Staphylococcus spp. (n = 57) and Gram-negative bacilli (n = 81). Overall mortality was 28.5% (85 patients). According to univariate analysis, mortality was associated with age over 60 years, anticipated death within 5 years, immunosuppression, shock, mechanical ventilation, bilateral pulmonary involvement, bacteremia, neutrophil count < 3500/mm3, total serum protein level < 45 g/l, serum creatinine > 15 mg/l, non-aspiration pneumonia, ineffective initial therapy and complications. Multivariate analysis selected only 5 factors significantly associated with prognosis: anticipated death within 5 years, shock, bacteremia, non-pneumonia-related complications and ineffective initial therapy. CONCLUSION: The effectiveness of the initial therapy appears to be the most significant prognosis factor and, as the one and only related to the initial medical intervention, suggests a need for permanent optimization of our antimicrobial strategies.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Community-Acquired Infections/*microbiology/*mortality/therapy, *Critical Care, Female, Hospital Mortality, Humans, Male, Middle Aged, Pneumonia/*microbiology/*mortality/therapy, Prognosis, Retrospective Studies, Risk Factors, Treatment Outcome
Pubmed
Création de la notice
29/04/2021 10:59
Dernière modification de la notice
30/04/2021 6:38
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