Spirituality includes notions as diverse as the purpose and meaning of one's life, the feeling of internal peace and harmony. Several epidemiological studies have shown evidence of an association between spirituality and mental, physical, as well as functional health status. These evidences, in conjunction with the high incidence of spiritual distress observed in older patients, increased the interest toward improving the assessment and management of spiritual distress in these older patients. Several ongoing studies investigate the benefits to expect from such intervention.