Plants have evolved unique membrane receptors that interpret native and foreign cues to coordinate plant life and adaptation. This large family of receptor proteins have evolved very diverse ectodomains, acquiring the capacity to sense ligands of very different chemical nature. A mechanistic understanding on how these signaling systems work will help to comprehend and unveil key cell biology questions. This review aims to focus on the latest receptor-ligands interactions and regulatory mechanism that have been structurally characterized, as well as new receptor folds.