Allostatic working memory processing in schizophrenia: Human and animal model coherence

Détails

ID Serval
serval:BIB_6607000CE16C
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Allostatic working memory processing in schizophrenia: Human and animal model coherence
Auteur⸱e⸱s
Cocchi Laurent, Preissmann Delphine, Do Kim Quang, Vianin Pascal, Schenk Françoise
ISBN
0302-282X
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
54
Série
Neuropsychobiology
Pages
14-15
Langue
anglais
Notes
SAPHIRID:61442
Résumé
The most evident symptoms of schizophrenia are severe impairment of cognitive functions like attention, abstract reasoning and working memory. The latter has been defined as the ability to maintain and manipulate on-line a limited amount of information. Whereas several studies show that working memory processes are impaired in schizophrenia, the specificity of this deficit is still unclear. Results obtained with a new paradigm, involving visuospatial, dynamic and static working memory processing, suggest that schizophrenic patients rely on a specific compensatory strategy. An animal model of schizophrenia with a transient deficit in glutathione during the development reveals similar substitutive processing, masking the impairment in working memory functions in specific test conditions only. Taken together, these results show coherence between working memory deficits in schizophrenic patients and in animal models. More generally, it is possible to consider that the pathological state may be interpreted as a reduced homeostatic reserve. However, this may be balanced in specific situations by efficient allostatic strategies. Thus, the pathological condition would remain latent in several situations, due to such allostatic regulations. However, to maintain a performance based on highly specific strategies requires in turn specific conditions, limitating adaptative resources in humans and in animals. In summary, we suggest that the psychological and physical load to maintain this rigid allostatic state is very high in patients and animal subjects.
Open Access
Oui
Création de la notice
10/03/2008 10:49
Dernière modification de la notice
20/08/2019 14:21
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