HIV-1 infection in the lymphoid organs
Détails
ID Serval
serval:BIB_65B7BB906C1B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HIV-1 infection in the lymphoid organs
Périodique
AIDS
ISSN
0269-9370 (Print)
Statut éditorial
Publié
Date de publication
11/1993
Volume
7 Suppl 2
Pages
S53-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Nov
Research Support, Non-U.S. Gov't
Review --- Old month value: Nov
Résumé
AIM: To develop a model of HIV disease progression. METHOD: Comparative analysis of viral burden and replication between peripheral blood and lymphoid organs and of the changes in viral distribution in the lymphoid tissue. RESULTS: In early-stage disease HIV-1-infected cells were sequestered in the lymphoid tissue, and the viral particles were concentrated and trapped in the germinal centers. The dichotomy in viral burden and viral replication between peripheral blood and lymphoid tissue was related to the histopathologic abnormalities associated with different stages of disease. CONCLUSIONS: These histopathologic abnormalities may not only explain the changes in viral distribution observed in the lymphoid tissue in different stages of the disease, but may also reflect different functional states of the immune system during the progression of HIV-1 infection from early- to late-stage disease.
Mots-clé
DNA, Viral/genetics/isolation & purification
HIV Infections/etiology/*microbiology/pathology
*HIV-1/genetics/isolation & purification/physiology
Humans
Lymphoid Tissue/*microbiology/pathology
RNA, Viral/genetics/isolation & purification
Time Factors
Virus Replication
Pubmed
Web of science
Création de la notice
25/01/2008 15:58
Dernière modification de la notice
20/08/2019 15:21