Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice
Détails
ID Serval
serval:BIB_64F593FB886E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice
Périodique
Gastroenterology
ISSN
0016-5085 (Print)
Statut éditorial
Publié
Date de publication
07/1995
Volume
109
Numéro
1
Pages
115-21
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
BACKGROUND & AIMS: Eradication of Helicobacter pylori infections in humans results in the healing of gastritis and gastric ulcers. This study used a mouse model to test whether oral vaccination can cure Helicobacter infection and gastritis. METHODS: Mice were infected with Helicobacter felis. Three weeks after infection, the mice were orally immunized with H. pylori urease B subunit. Control mice were simultaneously infected but sham immunized. RESULTS: Three to 8 weeks after oral immunization of H. felis-infected mice with recombinant H. pylori urease B subunit, the infection cleared and there was no evidence of gastritis. Vaccinated mice remained protected against two consecutive H. felis challenges. CONCLUSIONS: These results show that the lack of natural immunity against Helicobacter can be overcome by oral immunization and that vaccination offers a novel therapeutic approach to Helicobacter-induced gastritis.
Mots-clé
Administration, Oral
Animals
Disease Models, Animal
Female
Helicobacter Infections/immunology/prevention & control/*therapy
Helicobacter pylori/*enzymology
*Immunotherapy
Mice
Mice, Inbred BALB C
Recombinant Proteins/administration & dosage/therapeutic use
Recurrence
Urease/administration & dosage/*therapeutic use
Pubmed
Web of science
Création de la notice
25/01/2008 17:02
Dernière modification de la notice
20/08/2019 15:21