An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma.

Détails

Ressource 1Télécharger: BIB_64ED743CB2E8.P001.pdf (901.40 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_64ED743CB2E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma.
Périodique
Plos One
Auteur⸱e⸱s
Watkins A.J., Hamoudi R.A., Zeng N., Yan Q., Huang Y., Liu H., Zhang J., Braggio E., Fonseca R., de Leval L., Isaacson P.G., Wotherspoon A., McPhail E.D., Dogan A., Du M.Q.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
7
Numéro
9
Pages
e44997
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, transcriptomic and miRNomic data. High resolution array comparative genomic hybridization of 56 cases of SMZL delineated a minimally deleted region (2.8 Mb) at 7q32, but showed no evidence of any cryptic homozygous deletion or recurrent breakpoint in this region. Integrated transcriptomic analysis confirmed significant under-expression of a number of genes in this region in cases of SMZL with deletion, several of which showed hypermethylation. In addition, a cluster of 8 miRNA in this region showed under-expression in cases with the deletion, and three (miR-182/96/183) were also significantly under-expressed (P<0.05) in SMZL relative to other lymphomas. Genomic sequencing of these miRNA and IRF5, a strong candidate gene, did not show any evidence of somatic mutation in SMZL. These observations provide valuable guidance for further characterisation of 7q deletion.
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/11/2012 10:29
Dernière modification de la notice
20/08/2019 14:21
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