Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis.

Détails

ID Serval
serval:BIB_64972797007B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis.
Périodique
Cancer Research
Auteur⸱e⸱s
Dotto G.P.
ISSN
1538-7445 (Electronic)
ISSN-L
0008-5472
Statut éditorial
Publié
Date de publication
2011
Volume
71
Numéro
6
Pages
2029-2033
Langue
anglais
Résumé
Calcineurin is the only known serine-threonine phosphatase under calcium-calmodulin control and key regulator of the immune system. Treatment of patients with calcineurin-inhibitory drugs like cyclosporin A and FK506 to prevent graft rejection dramatically increases the risk of cutaneous squamous cell carcinoma, which is a major cause of death after organ transplants. Recent evidence indicates that suppression of calcineurin signaling, together with its impact on the immune system, exerts direct tumor-promoting effects in keratinocytes, enhancing cancer stem cell potential. The underlying mechanism involves interruption of a double negative regulatory axis, whereby calcineurin and nuclear factors of activated T-cell signaling inhibits expression of ATF3, a negative regulator of p53. The resulting suppression of keratinocyte cancer cell senescence is of likely clinical significance for the many patients under treatment with calcineurin inhibitors and may be of relevance for other cancer types in which altered calcium-calcineurin signaling plays a role.
Mots-clé
Activating Transcription Factor 3/metabolism, Animals, Calcineurin/metabolism, Carcinoma, Squamous Cell/metabolism, Carcinoma, Squamous Cell/pathology, Humans, Keratinocytes/metabolism, Keratinocytes/pathology, Models, Biological, NFATC Transcription Factors/metabolism, Neoplastic Stem Cells/metabolism, Neoplastic Stem Cells/pathology, Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/10/2011 13:32
Dernière modification de la notice
20/08/2019 14:20
Données d'usage