Better efficacy of methotrexate given by intramuscular injection than orally in patients with rheumatoid arthritis.

Détails

ID Serval
serval:BIB_64727FA53921
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Better efficacy of methotrexate given by intramuscular injection than orally in patients with rheumatoid arthritis.
Périodique
Annals of the rheumatic diseases
Auteur(s)
Wegrzyn J., Adeleine P., Miossec P.
ISSN
0003-4967 (Print)
ISSN-L
0003-4967
Statut éditorial
Publié
Date de publication
10/2004
Peer-reviewed
Oui
Volume
63
Numéro
10
Pages
1232-1234
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
To compare the clinical efficacy of methotrexate and tolerance to the drug in patients with rheumatoid arthritis who were switched from intramuscular to oral administration because of a shortage of the intramuscular preparation.
143 patients were switched from intramuscular to oral methotrexate. Of these, 47 were switched back to the intramuscular form. A multiple choice questionnaire was sent by mail to evaluate clinical and biological criteria of efficacy and tolerance.
When methotrexate was first switched from intramuscular to oral administration, increased disease activity, exacerbation of morning pain and hand stiffness, duration of morning stiffness, increased joint pain, and increased joint swelling were observed. There was a greater frequency of gastrointestinal symptoms, but without a significant increase in liver abnormalities. When intramuscular methotrexate became available again, 47 of the 143 patients were switched back and were followed for at least three months. On average, disease manifestations were improved and side effects reduced by the switch.
Methotrexate given intramuscularly had improved clinical efficacy with fewer side effects than given orally. Intramuscular methotrexate administration should be considered when rheumatoid arthritis remains active in spite of high dose oral methotrexate.
Mots-clé
Administration, Oral, Adult, Aged, Aged, 80 and over, Antirheumatic Agents/administration & dosage, Antirheumatic Agents/therapeutic use, Arthritis, Rheumatoid/drug therapy, Female, Humans, Injections, Intramuscular, Male, Methotrexate/administration & dosage, Methotrexate/therapeutic use, Middle Aged, Retrospective Studies, Severity of Illness Index, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/01/2020 8:57
Dernière modification de la notice
18/01/2020 7:26
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