The quest for the best: The impact of different EPI sequences on the sensitivity of random effect fMRI group analyses.

Détails

Ressource 1Télécharger: BIB_646E35B04671.P001.pdf (1797.58 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_646E35B04671
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The quest for the best: The impact of different EPI sequences on the sensitivity of random effect fMRI group analyses.
Périodique
Neuroimage
Auteur⸱e⸱s
Kirilina E., Lutti A., Poser B.A., Blankenburg F., Weiskopf N.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
126
Pages
49-59
Langue
anglais
Résumé
We compared the sensitivity of standard single-shot 2D echo planar imaging (EPI) to three advanced EPI sequences, i.e., 2D multi-echo EPI, 3D high resolution EPI and 3D dual-echo fast EPI in fixed effect and random effects group level fMRI analyses at 3T. The study focused on how well the variance reduction in fixed effect analyses achieved by advanced EPI sequences translates into increased sensitivity in the random effects group level analysis. The sensitivity was estimated in a functional MRI experiment of an emotional learning and a reward based learning tasks in a group of 24 volunteers. Each experiment was acquired with the four different sequences. The task-related response amplitude, contrast level and respective t-value were proxies for the functional sensitivity across the brain. All three advanced EPI methods increased the sensitivity in the fixed effects analyses, but standard single-shot 2D EPI provided a comparable performance in random effects group analysis when whole brain coverage and moderate resolution are required. In this experiment inter-subject variability determined the sensitivity of the random effects analysis for most brain regions, making the impact of EPI pulse sequence improvements less relevant or even negligible for random effects analyses. An exception concerns the optimization of EPI reducing susceptibility-related signal loss that translates into an enhanced sensitivity e.g. in the orbitofrontal cortex for multi-echo EPI. Thus, future optimization strategies may best aim at reducing inter-subject variability for higher sensitivity in standard fMRI group studies at moderate spatial resolution.
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/03/2016 18:00
Dernière modification de la notice
20/08/2019 14:20
Données d'usage