IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction.

Détails

Ressource 1Télécharger: BIB_6445CEECC43D.P001.pdf (1442.12 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_6445CEECC43D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction.
Périodique
Journal of Experimental Medicine
Auteur(s)
Bibert S., Roger T., Calandra T., Bochud M., Cerny A., Semmo N., Duong F.H., Gerlach T., Malinverni R., Moradpour D., Negro F., Müllhaupt B., Bochud P.Y.
Collaborateur(s)
Swiss Hepatitis C Cohort Study
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
210
Numéro
6
Pages
1109-1116
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish; Brief Definitive Report
Résumé
Approximately 3% of the world population is chronically infected with the hepatitis C virus (HCV), with potential development of cirrhosis and hepatocellular carcinoma. Despite the availability of new antiviral agents, treatment remains suboptimal. Genome-wide association studies (GWAS) identified rs12979860, a polymorphism nearby IL28B, as an important predictor of HCV clearance. We report the identification of a novel TT/-G polymorphism in the CpG region upstream of IL28B, which is a better predictor of HCV clearance than rs12979860. By using peripheral blood mononuclear cells (PBMCs) from individuals carrying different allelic combinations of the TT/-G and rs12979860 polymorphisms, we show that induction of IL28B and IFN-γ-inducible protein 10 (IP-10) mRNA relies on TT/-G, but not rs12979860, making TT/-G the only functional variant identified so far. This novel step in understanding the genetic regulation of IL28B may have important implications for clinical practice, as the use of TT/G genotyping instead of rs12979860 would improve patient management.
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/06/2013 11:51
Dernière modification de la notice
20/08/2019 15:20
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