Antibiotic prophylaxis in cardiovascular surgery: a prospective randomized comparative trial of one day cefazolin versus single dose cefuroxime

Détails

ID Serval
serval:BIB_642800A16A33
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antibiotic prophylaxis in cardiovascular surgery: a prospective randomized comparative trial of one day cefazolin versus single dose cefuroxime
Périodique
Drugs Under Experimental and Clinical Research
Auteur⸱e⸱s
Galbraith  U., Schilling  J., von Segesser  L. K., Carrel  T., Turina  M., Geroulanos  S.
ISSN
0378-6501
Statut éditorial
Publié
Date de publication
1993
Peer-reviewed
Oui
Volume
19
Numéro
5
Pages
229-34
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Résumé
With the intention of reducing prophylactic antibiotic dosage, previous studies in the Zurich University Hospital have shown that a one/day prophylactic antimicrobial regimen with cefazolin was as effective as a single dose of ceftriaxone. In this prospective randomized study one day cefazolin prophylaxis (1 g q 8 h i.v.) was compared with a single dose of cefuroxime prophylaxis (1.5 g). In cases of cardiopulmonary bypass 0.75 g was added in the priming solution. In case of re-operation prophylaxis was repeated. 496 patients were enrolled in the study protocol; 78 patients were subsequently excluded. Of the remaining patients 224 (158 male, 66 female, mean age 61) were in the cefazolin group and 194 (142 male and 52 female, mean age 60) in the cefuroxime group. Mean duration of the intensive care unit (ICU) stay was three days in both groups and mean hospital stay was 16 days in the cefazolin group and 15 days in the cefuroxime group. The overall postoperative infection rate was 15.3%; 18.8% in the cefazolin group and 11.3% in the cefuroxime group. The statistical differences were found as in trend (p = 0.095). The lower incidence of infectious complications in the single cefuroxime dose group may indicate an improvement in effectiveness of antimicrobial prophylaxis: it offers patients a reliable antimicrobial protection. In addition, the single dose prophylaxis has the advantage of easier handling, reduced dosage frequency and lower cost.
Mots-clé
Bacterial Infections/microbiology/mortality/prevention & control *Cardiovascular Surgical Procedures Cefazolin/administration & dosage/adverse effects/*therapeutic use Cefuroxime/administration & dosage/adverse effects/*therapeutic use Female Humans Male Middle Aged Postoperative Complications/mortality *Premedication Prospective Studies
Pubmed
Web of science
Création de la notice
14/02/2008 14:19
Dernière modification de la notice
20/08/2019 14:20
Données d'usage