Antioxidant supplementation in sepsis and systemic inflammatory response syndrome

Détails

ID Serval
serval:BIB_6406FE961C75
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Antioxidant supplementation in sepsis and systemic inflammatory response syndrome
Périodique
Critical Care Medicine
Auteur(s)
Berger  M. M., Chiolero  R. L.
ISSN
0090-3493 (Print)
Statut éditorial
Publié
Date de publication
09/2007
Volume
35
Numéro
9 Suppl
Pages
S584-90
Notes
Journal Article --- Old month value: Sep
Résumé
OBJECTIVE: Summarize the current knowledge about oxidative stress-related organ dysfunction in inflammatory and septic conditions, and its potential prevention and treatment by antioxidants in critically ill patients, focusing on naturally occurring antioxidants and clinical trials. STUDY SELECTION: PubMed, MEDLINE, and personal database search. SYNTHESIS: Plasma concentrations of antioxidant micronutrients are depressed during critical illness and especially during sepsis. The causes of these low levels include losses with biological fluids, low intakes, dilution by resuscitation fluids, as well as systemic inflammatory response syndrome-mediated redistribution of micronutrients from plasma to tissues. Numerous clinical trials have been conducted, many of which have shown beneficial effects of supplementation. Interestingly, among the candidates, glutamine, glutathione, and selenium are linked with the potent glutathione peroxidase enzyme family at some stage of their synthesis and metabolism. CONCLUSIONS: Three antioxidant nutrients have demonstrated clinical benefits and reached level A evidence: a) selenium improves clinical outcome (infections, organ failure); b) glutamine reduces infectious complication in large-sized trials; and c) the association of eicosapentaenoic acid and micronutrients has significant anti-inflammatory effects. Other antioxidants are still on the clinical benchmark level, awaiting well-designed clinical trials.
Pubmed
Web of science
Création de la notice
24/01/2008 17:52
Dernière modification de la notice
20/08/2019 15:20
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