Renal effects of adenosine A1-receptor blockade with 8-cyclopentyl-1,3-dipropylxanthine in hypoxemic newborn rabbits.
Détails
ID Serval
serval:BIB_63A8D1513269
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Renal effects of adenosine A1-receptor blockade with 8-cyclopentyl-1,3-dipropylxanthine in hypoxemic newborn rabbits.
Périodique
Pediatric Research
ISSN
0031-3998
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
54
Numéro
3
Pages
400-405
Langue
anglais
Résumé
The key role of intrarenal adenosine in mediating the hypoxemic acute renal insufficiency in newborn rabbits has been well demonstrated using the nonspecific adenosine antagonist theophylline. The present study was designed to define the role of adenosine A1 receptors during systemic hypoxemia by using the specific A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX). Renal function parameters were assessed in 31 anesthetized and mechanically ventilated newborn rabbits. In normoxia, DPCPX infusion induced a significant increase in diuresis (+44%) and GFR (+19%), despite a significant decrease in renal blood flow (RBF) (-22%) and an increase in renal vascular resistance (RVR) (+37%). In hypoxemic conditions, diuresis (-19%), GFR (-26%), and RBF (-35%) were decreased, whereas RVR increased (+33%). DPCPX administration hindered the hypoxemia-induced decrease in GFR and diuresis. However, RBF was still significantly decreased (-27%), whereas RVR increased (+22%). In all groups, the filtration fraction increased significantly. The overall results support the hypothesis that, in physiologic conditions, intrarenal adenosine plays a key role in regulating glomerular filtration in the neonatal period through preferential A1-mediated afferent vasoconstriction. During a hypoxemic stress, the A1-specific antagonist DPCPX only partially prevented the hypoxemia-induced changes, as illustrated by the elevated RVR and drop in RBF. These findings imply that the contribution of intrarenal adenosine to the acute adverse effects of hypoxemia might not be solely mediated via the A1 receptor.
Mots-clé
Animals, Animals, Newborn, Anoxia/metabolism, Glomerular Filtration Rate/physiology, Hemodynamics/physiology, Kidney/physiology, Rabbits, Random Allocation, Receptor, Adenosine A1/antagonists & inhibitors, Receptor, Adenosine A1/metabolism, Xanthines/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/07/2009 13:15
Dernière modification de la notice
20/08/2019 14:20