A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease.
Détails
ID Serval
serval:BIB_6382C64D159D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease.
Périodique
Blood
ISSN
1528-0020 (Electronic)
ISSN-L
0006-4971
Statut éditorial
Publié
Date de publication
2011
Volume
118
Numéro
20
Pages
5401-5408
Langue
anglais
Résumé
To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/12/2011 11:35
Dernière modification de la notice
20/08/2019 15:20