Thyroid carcinoma with papillary and squamous features: report of a case with histogenetic considerations.

Détails

ID Serval
serval:BIB_636A7186F264
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Thyroid carcinoma with papillary and squamous features: report of a case with histogenetic considerations.
Périodique
Pathology, Research and Practice
Auteur⸱e⸱s
Rausch T., Benhattar J., Sutter M., Andrejevic-Blant S.
ISSN
1618-0631[electronic], 0344-0338[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
206
Numéro
4
Pages
263-269
Langue
anglais
Résumé
We present a case of an 82-year-old female with a painless left latero-cervical swelling, which increased in size over the course of 6 months, compressing adjacent organs. The histopathological examination, following dissection of the left thyroid lobe and ipsilateral cervical lymph nodes, yielded two intermingled morphologically distinct histotypes that included conventional papillary thyroid carcinoma (PTC) and poorly differentiated squamous cell carcinoma (SCC) with cystic features. The clinical presentation, the immunophenotype, and the genotype, especially of the malignant squamous component with partial expression of TTF1, marked expression of p63 and mutation of BRAF, were consistent with the diagnosis of a papillary thyroid carcinoma with squamous component. The possibility of a squamous cell carcinoma of unknown origin metastasizing to a primary papillary thyroid carcinoma cannot be completely ruled out. This particular presentation of thyroid carcinoma carries a poor prognosis in 20% of cases, with high recurrence rates and distant metastasis.
Mots-clé
Aged, 80 and over, Carcinoma, Papillary/genetics, Carcinoma, Papillary/pathology, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/pathology, Fatal Outcome, Female, Humans, Immunohistochemistry, Immunophenotyping, Mixed Tumor, Malignant/genetics, Mixed Tumor, Malignant/pathology, Mutation/genetics, Prognosis, Proto-Oncogene Proteins B-raf/genetics, Thyroid Neoplasms/genetics, Thyroid Neoplasms/pathology
Pubmed
Web of science
Création de la notice
08/06/2009 16:06
Dernière modification de la notice
20/08/2019 14:20
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