Prior parity reduces post-coital diurnal and nocturnal prolactin surges in rats

Détails

ID Serval
serval:BIB_6343B4467883
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prior parity reduces post-coital diurnal and nocturnal prolactin surges in rats
Périodique
Life Sciences
Auteur(s)
Bridges  R. S., Felicio  L. F., Pellerin  L. J., Stuer  A. M., Mann  P. E.
ISSN
0024-3205 (Print)
Statut éditorial
Publié
Date de publication
1993
Volume
53
Numéro
5
Pages
439-45
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Résumé
Mating stimuli received by female rats activate a neuroendocrine mnemonic system which produces daily diurnal and nocturnal prolactin (PRL) surges for the first half of gestation, surges which help maintain corpora lutea function and a viable pregnancy. Since these PRL surges may be regulated in part by endogenous opioids and opioid sensitivity declines as a function of multiple births, we decided to investigate the possibility that prior parity might affect the post-coital diurnal and nocturnal PRL surges, reducing their magnitude and/or occurrence. Age-matched, nulliparous and primiparous rats were mated to males from our colony. On days 5 or 10 of pregnancy females received jugular catheters. Blood samples were collected at regular intervals from 1000 h on day 7 to 1000 h on day 8, and from 1000 h on day 12 to 1000 h on day 13 of gestation in separate sets of multigravid and primigravid rats. Measurement of plasma PRL by radioimmunoassay revealed that prior reproductive experience altered the patterns and levels of plasma PRL. Plasma PRL levels were significantly reduced during both the diurnal and nocturnal surges on days 7-8 in multigravid rats when compared with levels in primigravid rats. No differences in PRL levels were found between primigravid and multigravid groups on days 12 to 13 of gestation. The changes in diurnal and nocturnal PRL surges during early pregnancy indicate that prior parity reduces the subsequent secretion of PRL, possibly by altering the neuroendocrine regulation of this hormone.
Mots-clé
Animals Circadian Rhythm Copulation/physiology Female Parity/*physiology Pregnancy Prolactin/blood/*secretion Radioimmunoassay Rats Rats, Sprague-Dawley
Pubmed
Web of science
Création de la notice
24/01/2008 14:16
Dernière modification de la notice
20/08/2019 15:19
Données d'usage