Leptin modulates inflammatory cytokine and neuroendocrine responses to endotoxin in the primate.

Détails

ID Serval
serval:BIB_6302E7941659
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Leptin modulates inflammatory cytokine and neuroendocrine responses to endotoxin in the primate.
Périodique
Endocrinology
Auteur(s)
Xiao E., Xia-Zhang L., Vulliémoz N.R., Ferin M., Wardlaw S.L.
ISSN
0013-7227 (Print)
ISSN-L
0013-7227
Statut éditorial
Publié
Date de publication
10/2003
Peer-reviewed
Oui
Volume
144
Numéro
10
Pages
4350-4353
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Leptin, which plays a crucial role in regulating energy balance, can also modulate the inflammatory response. Although leptin-deficient rodents are more sensitive to the toxic effects of bacterial endotoxin, it is unknown if leptin can modulate inflammatory cytokine or neuroendocrine responses to inflammation in a primate model. We have therefore studied the effects of leptin on plasma cytokine and hypothalamic-pituitary-adrenal responses to endotoxin (5 microg iv) in nine ovariectomized rhesus monkeys. Human leptin (50 microg/h) or saline was infused iv for 16 h before and 4 h after endotoxin injection; mean plasma leptin increased from 3.6 +/- 1.0 ng/ml to 18 +/- 1.7 ng/ml (P < 0.001). Leptin infusion had no effect on baseline plasma cytokine and hormone levels before endotoxin injection. As expected, endotoxin stimulated TNF-alpha, IL-6, IL-1 receptor antagonist (IL-1ra), ACTH, and cortisol in the saline-infused animals (P < 0.001). There was a significant attenuation of the IL-6 (P < 0.005) and cortisol (P < 0.001) responses (repeated measures ANOVA) to endotoxin in the leptin-infused animals. There was a significant reduction (by paired analysis) in the responses of the leptin compared with saline-treated animals: 47% for TNF-alpha, 48% for IL-6, 30% for IL1ra, 42% for ACTH, and 22% for cortisol (P < 0.05). We conclude that an increase in circulating leptin, within the physiological range of our monkey colony, can blunt the inflammatory cytokine and hypothalamic-pituitary-adrenal responses to an inflammatory challenge. These results, coupled with our recent finding that endotoxin stimulates leptin release in the monkey, demonstrate that leptin can be both released in response to inflammatory cytokines and act to attenuate the responses to these cytokines.

Mots-clé
Animals, Cytokines/metabolism, Endotoxins/pharmacology, Female, Humans, Inflammation Mediators/metabolism, Infusions, Intravenous, Leptin/administration & dosage, Leptin/blood, Leptin/pharmacology, Macaca mulatta, Neurosecretory Systems/drug effects, Neurosecretory Systems/metabolism, Ovariectomy
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/07/2017 9:07
Dernière modification de la notice
07/10/2019 5:26
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