Overdiagnosis and overtreatment of thyroid cancer: A population-based temporal trend study.

Détails

Ressource 1Télécharger: BIB_62F7DDC7EA5F.pdf (891.13 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_62F7DDC7EA5F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Overdiagnosis and overtreatment of thyroid cancer: A population-based temporal trend study.
Périodique
PloS one
Auteur(s)
Jegerlehner S., Bulliard J.L., Aujesky D., Rodondi N., Germann S., Konzelmann I., Chiolero A.
Collaborateur(s)
NICER Working Group
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
12
Numéro
6
Pages
e0179387
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The increase in incidence of thyroid cancer during the last decades without concomitant rise in mortality may reflect the growing detection of indolent forms of thyroid cancer, and may have fueled unnecessary thyroidectomies. Our aim was therefore, to compare recent secular trends in surgical intervention rate for thyroid cancer with the incidence and mortality of thyroid cancer to assess overdiagnosis and resulting overtreatment.
We conducted a population-based temporal trend study in Switzerland from 1998 to 2012. All cases of invasive thyroid cancer, deaths from thyroid cancer, and cancer-related thyroidectomies were analyzed. We calculated changes in age-standardized thyroid cancer incidence rates, stratified by histologic subtype and tumor stage, thyroid cancer-specific mortality, and thyroidectomy rates.
Between 1998 and 2012, the age-standardized annual incidence of thyroid cancer increased from 5.9 to 11.7 cases/100,000 among women (annual mean absolute increase: +0.43/100,000/year) and from 2.7 to 3.9 cases/100,000 among men (+0.11/100,000/year). The increase was limited to the papillary subtype, the most indolent form of thyroid cancer. The incidence of early stages increased sharply, the incidence of advanced stages increased marginally, and the mortality from thyroid cancer decreased slightly. There was a three- to four-fold increase in the age-standardized annual thyroidectomy rate in both sexes.
We observed a large increase in the incidence of thyroid cancer, limited to papillary and early stage tumors, with a three- to four-fold parallel increase in thyroidectomy. The mortality slightly decreased. These findings suggest that a substantial and growing part of the detected thyroid cancers are overdiagnosed and overtreated.
Targeted screening and diagnostic strategies are warranted to avoid overdetection and unnecessary treatment of thyroid cancers.

Pubmed
Web of science
Open Access
Oui
Création de la notice
19/06/2017 11:14
Dernière modification de la notice
20/08/2019 15:19
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