First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study.

Détails

Ressource 1Télécharger: 32412159_BIB_62886B377225.pdf (8645.04 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: CC BY-NC-ND 4.0
Document(s) secondaire(s)
Télécharger: First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study.pdf (545.29 [Ko])
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_62886B377225
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study.
Périodique
American journal of transplantation
Auteur⸱e⸱s
Tschopp J., L'Huillier A.G., Mombelli M., Mueller N.J., Khanna N., Garzoni C., Meloni D., Papadimitriou-Olivgeris M., Neofytos D., Hirsch H.H., Schuurmans M.M., Müller T., Berney T., Steiger J., Pascual M., Manuel O., van Delden C.
Collaborateur⸱rice⸱s
Swiss Transplant Cohort Study (STCS)
Contributeur⸱rice⸱s
Amico P., Aubert J.D., Banz V., Beldi G., Benden C., Berger C., Binet I., Bochud P.Y., Branca S., Bucher H., Carell T., Catana E., Chalandon Y., de Geest S., de Rougemont O., Dickenmann M., Duchosal M., Elkrief L., Fehr T., Ferrari-Lacraz S., Garzoni C., Soccal P.G., Gaudet C., Giostra E., Golshayan D., Hadaya K., Halter J., Hauri D., Heim D., Hess C., Hillinger S., Hirsch H.H., Hofbauer G., Huynh-Do U., Immer F., Klaghofer R., Koller M., Laesser B., Laube G., Lehmann R., Lovis C., Majno P., Manuel O., Marti H.P., Martin P.Y., Martinelli M., Meylan P., Mueller N.J., Müller A., Müller T., Müllhaupt B., Pascual M., Passweg J., Posfay-Barbe K., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schanz U., Schaub S., Schnyder A., Schuurmans M., Seiler C., Sprachta J., Stampf S., Steinack C., Steiger J., Stirnimann G., Toso C., Van Delden C., Venetz J.P., Villard J., Wick M., Wilhelm M., Yerly P.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Statut éditorial
Publié
Date de publication
10/2020
Peer-reviewed
Oui
Volume
20
Numéro
10
Pages
2876-2882
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study
Publication Status: ppublish
Résumé
Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, comprehensive data of SARS-CoV-2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%), and diarrhea (33%). Ninety-five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow-up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS-CoV-2 infection in middle-aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts.
Mots-clé
Aged, Betacoronavirus, Comorbidity, Coronavirus Infections/epidemiology, Disease Transmission, Infectious/prevention & control, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Organ Transplantation/methods, Pandemics, Pneumonia, Viral/epidemiology, Postoperative Complications/epidemiology, Prospective Studies, Survival Rate/trends, Switzerland/epidemiology, Transplant Recipients, clinical research/ practice, complication: infectious, infection and infectious agents, infection and infectious agents - viral, infectious disease
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/06/2020 20:19
Dernière modification de la notice
27/01/2024 7:36
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