Synthesis and anticancer activity of long-chain isonicotinic ester ligand-containing arene ruthenium complexes and nanoparticles

Détails

ID Serval
serval:BIB_624C20BDFB9B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Synthesis and anticancer activity of long-chain isonicotinic ester ligand-containing arene ruthenium complexes and nanoparticles
Périodique
Journal of cluster science
Auteur(s)
Süss-Fink G., Khan F-A., Juillerat-Jeanneret L., Dyson P.J., Renfrew A.K.
ISSN
1040-7278
Statut éditorial
Publié
Date de publication
04/2010
Peer-reviewed
Oui
Volume
21
Pages
313-324
Langue
anglais
Résumé
Arene ruthenium complexes containing long-chain N-ligands L1 = NC5H4-4-COO-C6H4-4-O-(CH2)9-CH3 or L2 = NC5H4-4-COO-(CH2)10-O-C6H4-4-COO-C6H4-4-C6H4-4-CN derived from isonicotinic acid, of the type [(arene)Ru(L)Cl2] (arene = C6H6, L = L1: 1; arene = p-MeC6H4Pr i , L = L1: 2; arene = C6Me6, L = L1: 3; arene = C6H6, L = L2: 4; arene = p-MeC6H4Pr i , L = L2: 5; arene = C6Me6, L = L2: 6) have been synthesized from the corresponding [(arene)RuCl2]2 precursor with the long-chain N-ligand L in dichloromethane. Ruthenium nanoparticles stabilized by L1 have been prepared by the solvent-free reduction of 1 with hydrogen or by reducing [(arene)Ru(H2O)3]SO4 in ethanol in the presence of L1 with hydrogen. These complexes and nanoparticles show a high anticancer activity towards human ovarian cell lines, the highest cytotoxicity being obtained for complex 2 (IC50 = 2 μM for A2780 and 7 μM for A2780cisR)
Mots-clé
ruthenium nanoparticles, anticancer drugs, bioorganometallic chemistry, isonicotinic ester ligands, arene ruthenium complexes
Web of science
Création de la notice
07/10/2010 10:41
Dernière modification de la notice
20/08/2019 14:19
Données d'usage