Reproducibility of PET activation studies: lessons from a multi-center European experiment. EU concerted action on functional imaging.

Détails

ID Serval
serval:BIB_6211327AE921
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reproducibility of PET activation studies: lessons from a multi-center European experiment. EU concerted action on functional imaging.
Périodique
Neuroimage
Auteur⸱e⸱s
Poline J.B., Vandenberghe R., Holmes A.P., Friston K.J., Frackowiak R.S.
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
1996
Volume
4
Numéro
1
Pages
34-54
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
PET activation studies are performed widely to study human brain function. The question of reproducibility, reliability, and comparability of the results of such experiments has never been addressed on a large scale. Recently, 12 European PET centers performed the same cognitive activation experiment in a European Union funded concerted action. The experiment involved a standardized and validated cross-lingual experimental and control task involving verbal fluency. Each center contributed at least 6 subjects. In total there were 77 subjects and 247 scans in each of the two conditions, giving 494 scans in total. We have analyzed each center's dataset and pooled datasets using statistical parametric mapping. We present results that address the consistency of these analyses, discuss the factors that influence their sensitivity, and comment on a number of related methodological issues. We used a MANOVA to test for center, condition, and centre by condition effects and found a strong condition and center effect and weaker interactions. The main effect determining reproducibility was the overall sensitivity of the experiment, to which the scanner and number of scans contribute in a major way, with a marked advantage for 3D scanners and a large field of view. An important conclusion is that data from different centers can be pooled to improve the reliability of results, which is of particular importance for studies in patients with rare conditions.
Mots-clé
Adult, Arousal/physiology, Attention/physiology, Brain Mapping, Data Collection, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Male, Reproducibility of Results, Speech Perception/physiology, Tomography, Emission-Computed, Verbal Behavior/physiology, Verbal Learning/physiology
Pubmed
Web of science
Création de la notice
16/09/2011 18:38
Dernière modification de la notice
20/08/2019 14:19
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