In experimental color research, one must ensure that color is displayed and described reliably. When monitors are involved, colors are displayed through device-dependent color systems. However, these values must be translated into device-independent color systems to interpret what people perceive, often involving techniques such as gamma correction. We sought to explore the feasibility of estimating gamma instead of relying on direct gamma measurements, which typically require specialized equipment like a chromameter. Potential solutions include a computerized perception-based gamma estimation task or adopting the industry-standard gamma value of 2.2. We compared these two solutions against the chromameter measurements in the context of a color-matching task. Thirty-nine participants visually matched red, yellow, green, and blue physical objects using a computerized color picker. Starting from these color choices, we applied two RGB-to-CIELab color conversion methods: one using a perception-based gamma estimation and another using the industry-standard gamma. Color values obtained with the chromameter differed from the other two methods by 6–15 JNDs. Small differences existed between the results obtained using the perception-based task and the industry-standard gamma. Thus, we conclude that when standard viewing conditions cannot be assumed, adopting a gamma value of 2.2 should suffice.