Analysis of the cornified cell envelope in lamellar ichthyosis

Détails

ID Serval
serval:BIB_61D3FF082C3A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Analysis of the cornified cell envelope in lamellar ichthyosis
Périodique
Archives of Dermatology
Auteur(s)
Hohl  D., Huber  M., Frenk  E.
ISSN
0003-987X (Print)
Statut éditorial
Publié
Date de publication
05/1993
Volume
129
Numéro
5
Pages
618-24
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
BACKGROUND--Loricrin and involucrin are major precursor proteins to the cornified cell envelope expressed late in epidermal differentiation. Involucrin expression starts in the upper spinous layers in normal human epidermis and precedes loricrin expression, which is restricted to the granular layer. Subsequently, both proteins become cross-linked by the activity of transglutaminases TGK/E as major components of the cornified cell envelope by N epsilon-(gamma-glutamyl)lysine isopeptide bonds. In this study, three cases of lamellar ichthyosis were analyzed by immunohistologic study with antibodies to loricrin, involucrin, filaggrin, and transglutaminase TGK. OBSERVATIONS--A high expression of loricrin and involucrin with a peculiar and abnormal cytoplasmic staining concurred with a diminished cytoplasmic staining of transglutaminase TGK as assessed by antibodies B.C.1 and K.D.3. This pattern was absent in a collodion baby at birth but present 2 weeks later before a phenotype of lamellar ichthyosis appeared clinically. CONCLUSIONS--The results suggest that in our cases of lamellar ichthyosis, (1) disturbed membrane anchorage of transglutaminase TGK could alter loricrin and involucrin cross-linkage and the formation of the cornified cell envelope and that (2) immunohistologic study might serve as an early diagnostic and prognostic tool in the treatment of collodion babies.
Mots-clé
Cell Membrane/*pathology Humans Ichthyosis, Lamellar/metabolism/*pathology Membrane Proteins/*analysis/biosynthesis Protein Precursors/*analysis/biosynthesis Transglutaminases/*analysis/biosynthesis
Pubmed
Web of science
Création de la notice
25/01/2008 17:36
Dernière modification de la notice
20/08/2019 15:18
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