Differential gene expression studies to explore the molecular pathophysiology of Down syndrome

Détails

ID Serval
serval:BIB_618FD857F536
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Differential gene expression studies to explore the molecular pathophysiology of Down syndrome
Périodique
Brain Research. Brain Research Reviews
Auteur⸱e⸱s
Antonarakis  S. E., Lyle  R., Chrast  R., Scott  H. S.
ISSN
0165-0173 (Print)
Statut éditorial
Publié
Date de publication
10/2001
Volume
36
Numéro
2-3
Pages
265-74
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Résumé
Trisomy 21, which causes Down syndrome, is the model human disorder due to the presence of a supernumerary chromosome. The completion of the sequence of chromosome 21 and the development of appropriate animal models now provide the molecular infrastructure and the reagents to elucidate the molecular mechanisms of the different phenotypes of Down syndrome. The study of the overexpression of single genes, and the dysregulation of global gene expression will enhance the understanding of the pathogenesis of the cognitive impairment of this syndrome.
Mots-clé
Animals Base Sequence/physiology Brain/*abnormalities/pathology/physiopathology Chromosomes, Human, Pair 21/*genetics Disease Models, Animal Down Syndrome/*genetics/*physiopathology Gene Expression Regulation, Developmental/*physiology Humans Mice Mice, Neurologic Mutants/abnormalities/genetics/metabolism Phenotype
Pubmed
Web of science
Création de la notice
24/01/2008 14:12
Dernière modification de la notice
20/08/2019 14:18
Données d'usage