Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma.
Détails
ID Serval
serval:BIB_617BC0CBBFB7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma.
Périodique
Journal of Biological Chemistry
ISSN
0021-9258[print], 0021-9258[linking]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
282
Numéro
41
Pages
29946-29957
Langue
anglais
Résumé
Peroxisome proliferator-activated receptor gamma (PPARgamma) is an essential regulator of adipocyte differentiation, maintenance, and survival. Deregulations of its functions are associated with metabolic diseases. We show here that deletion of one PPARgamma allele not only affected lipid storage but, more surprisingly, also the expression of genes involved in glucose uptake and utilization, the pentose phosphate pathway, fatty acid synthesis, lipolysis, and glycerol export as well as in IR/IGF-1 signaling. These deregulations led to reduced circulating adiponectin levels and an energy crisis in the WAT, reflected in a decrease to nearly half of its intracellular ATP content. In addition, there was a decrease in the metabolic rate and physical activity of the PPARgamma(+/-) mice, which was abolished by thiazolidinedione treatment, thereby linking regulation of the metabolic rate and physical activity to PPARgamma. It is likely that the PPARgamma(+/-) phenotype was due to the observed WAT dysfunction, since the gene expression profiles associated with metabolic pathways were not affected either in the liver or the skeletal muscle. These findings highlight novel roles of PPARgamma in the adipose tissue and underscore the multifaceted action of this receptor in the functional fine tuning of a tissue that is crucial for maintaining the organism in good health.
Mots-clé
Adiponectin/blood, Adipose Tissue/metabolism, Animals, Gene Deletion, Glycerol/chemistry, Hypoglycemic Agents/pharmacology, Liver/metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Biological, Muscle, Skeletal/metabolism, PPAR gamma/genetics, PPAR gamma/physiology, Thiazolidinediones/pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:27
Dernière modification de la notice
20/08/2019 15:18