Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure.

Détails

ID Serval
serval:BIB_617484B3F2CC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure.
Périodique
Science translational medicine
Auteur(s)
Zinsstag J., Lechenne M., Laager M., Mindekem R., Naïssengar S., Oussiguéré A., Bidjeh K., Rives G., Tessier J., Madjaninan S., Ouagal M., Moto D.D., Alfaroukh I.O., Muthiani Y., Traoré A., Hattendorf J., Lepelletier A., Kergoat L., Bourhy H., Dacheux L., Stadler T., Chitnis N.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Statut éditorial
Publié
Date de publication
20/12/2017
Peer-reviewed
Oui
Volume
9
Numéro
421
Pages
eaaf6984
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Despite the existence of effective rabies vaccines for dogs, dog-transmitted human rabies persists and has reemerged in Africa. Two consecutive dog vaccination campaigns took place in Chad in 2012 and 2013 (coverage of 71% in both years) in the capital city of N'Djaména, as previously published. We developed a deterministic model of dog-human rabies transmission fitted to weekly incidence data of rabid dogs and exposed human cases in N'Djaména. Our analysis showed that the effective reproductive number, that is, the number of new dogs infected by a rabid dog, fell to below one through November 2014. The modeled incidence of human rabies exposure fell to less than one person per million people per year. A phylodynamic estimation of the effective reproductive number from 29 canine rabies virus genetic sequences of the viral N-protein confirmed the results of the deterministic transmission model, implying that rabies transmission between dogs was interrupted for 9 months. However, new dog rabies cases appeared earlier than the transmission and phylodynamic models predicted. This may have been due to the continuous movement of rabies-exposed dogs into N'Djaména from outside the city. Our results show that canine rabies transmission to humans can be interrupted in an African city with currently available dog rabies vaccines, provided that the vaccination area includes larger adjacent regions, and local communities are informed and engaged.
Mots-clé
Animals, Basic Reproduction Number, Chad, Cities, Computer Simulation, Dogs, Humans, Incidence, Models, Biological, Phylogeny, Rabies/epidemiology, Rabies/immunology, Rabies/transmission, Rabies/virology, Rabies Vaccines/immunology, Stochastic Processes, Vaccination/veterinary
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/08/2018 10:59
Dernière modification de la notice
21/08/2019 6:17
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