Liver glycerokinase deficiency in man with hyperglycerolaemia and hypertriglyceridaemia

Détails

ID Serval
serval:BIB_6173B6CEE4BA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Liver glycerokinase deficiency in man with hyperglycerolaemia and hypertriglyceridaemia
Périodique
European Journal of Clinical Investigation
Auteur(s)
Pometta  D., Suenram  A., von der Weid  N., Widmann  J. J.
ISSN
0014-2972 (Print)
Statut éditorial
Publié
Date de publication
04/1984
Volume
14
Numéro
2
Pages
103-6
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
Hyperglycerolaemia and glyceroluria is described in a patient who presented transient dietary-induced hypertriglyceridaemia. The increased glycerol in blood and urine was related to glycerokinase deficiency as evidenced by a hepatic tissue glycerokinase activity of one tenth (4.8 X 10(-5) mmol g-1 min-1) of that of normoglycerolaemic subjects (5.9 X 10(-4) ). As triglycerides are routinely determined by an enzymatic method after hydrolysis to glycerol, the differential diagnosis between true hypertriglyceridaemia and hyperglycerolaemia may prove difficult. Persisting "hypertriglyceridaemia' despite adequate dietary and drug treatment should suggest the existence of undiagnosed hyperglycerolaemia .
Mots-clé
Adult Cholesterol/blood Glycerol/*blood/urine Glycerol Kinase/*deficiency Humans Hyperlipidemias/blood/*enzymology Hyperlipoproteinemia Type IV/blood Liver/*enzymology Male Phosphotransferases/*deficiency Triglycerides/*blood
Pubmed
Web of science
Création de la notice
25/01/2008 11:35
Dernière modification de la notice
20/08/2019 15:18
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